Ataxin2 functions via CrebA to mediate Huntingtin toxicity in circadian clock neurons.
Disrupted circadian rhythms is a prominent and early feature of neurodegenerative diseases including Huntington's disease (HD). In HD patients and animal models, striatal and hypothalamic neurons expressing molecular circadian clocks are targets of mutant Huntingtin (mHtt) pathogenicity. Yet how mHt...
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| Principais autores: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science (PLoS)
2019-10-01
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| coleção: | PLoS Genetics |
| Acesso em linha: | https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1008356&type=printable |
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