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Distinctive Mediating Effects of Subcortical Structure Changes on the Relationships Between Amyloid or Vascular Changes and Cognitive Decline

Objective: We investigated the mediation effects of subcortical volume change in the relationship of amyloid beta (Aβ) and lacune with cognitive function in patients with mild cognitive impairment (MCI).Methods: We prospectively recruited 101 patients with MCI who were followed up with neuropsycholo...

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Principais autores: Na-Yeon Jung, Jeong-Hyeon Shin, Hee Jin Kim, Hyemin Jang, Seung Hwan Moon, Seung Joo Kim, Yeshin Kim, Soo Hyun Cho, Ko Woon Kim, Jun Pyo Kim, Young Hee Jung, Sung Tae Kim, Eun-Joo Kim, Duk L. Na, Jacob W. Vogel, Sangjin Lee, Joon-Kyung Seong, Sang Won Seo
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021-12-01
coleção:Frontiers in Neurology
Assuntos:
mediation
subcortical structure
amyloid
lacune
cognition
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fneur.2021.762251/full
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