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Reduced eccDNA content in idiopathic asthenozoospermia sperm is associated with compromised DNA repair capacity and elevated DNA damage

Abstract Background Despite representing approximately 30% of male infertility cases, idiopathic asthenozoospermia (iAZS) remains etiologically uncharacterized. Extrachromosomal circular DNA (eccDNA) is mobile and circular DNA outside of linear chromosomes. Although eccDNA has been identified in hum...

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Principais autores: Zilong Wang, Changze Song, Xiaoning Hong, Jiaying Yu, Zhen Xu, Peng Han, Chunxiao He, Shuang Mao, Zhenghao Li, Huisheng Yuan, Xinkun Wang, Jiawen Zhai, SenBao Tan, Weiwen Fan, Yuan Xu, Tianzhi Zhang, Zheng Yang, Shengyun Lin, Wenli Zhu, Lei Huang, Chengchao Chen, Gang Zou, Wenbin Chen, Wei Lv, Lars Bolund, Lin Lin, Yonglun Luo, Feng Zhang, Fengbiao Mao, Jiang Li, Xi Xiang
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2026-03-01
coleção:Cellular & Molecular Biology Letters
Assuntos:
Extrachromosomal circular DNA
Idiopathic asthenozoospermia
Sperm motility
Male fertility
Transposable element
DNA repair
Acesso em linha:https://doi.org/10.1186/s11658-026-00857-4
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