Greater Durability and Protection against Herpes Simplex Viral Disease following Immunization of Mice with Single-Cycle ΔgD-2 Compared to an Adjuvanted Glycoprotein D Protein Vaccine

Herpes simplex viruses (HSV) cause chronic infections with significant morbidity. Prior vaccines, designed to generate neutralizing antibodies (nAbs) targeting glycoprotein D (gD), failed to provide durable protection. We adopted a different strategy and evaluated a single-cycle virus deleted in gD...

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Principais autores:	Aakash Mahant Mahant, Matthew S. Gromisch, Leah Kravets, Clare Burn Aschner, Betsy C. Herold
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2023-08-01
coleção:	Vaccines
Assuntos:	herpes simplex virus vaccine durability antibody-dependent cellular cytotoxicity single-cycle DgD-2 vaccine glycoprotein D subunit vaccine
Acesso em linha:	https://www.mdpi.com/2076-393X/11/8/1362
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