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Effective Synthesis and Antifouling Activity of Dolastatin 16 Derivatives

Some derivatives of dolastatin 16, a depsipeptide natural product first obtained from the sea hare <i>Dolabella auricularia</i>, were synthesized through second-generation synthesis of two unusual amino acids, dolaphenvaline and dolamethylleuine. The second-generation synthesis enabled derivatizatio...

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Principais autores: Loida O. Casalme, Keisuke Katayama, Yoshiki Hayakawa, Kensuke Nakamura, Arisa Yamauchi, Yasuyuki Nogata, Erina Yoshimura, Fuyuhiko Matsuda, Taiki Umezawa
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2022-02-01
Serier:Marine Drugs
Fag:
natural product
antifouling
dolastatin 16
peptide
<i>Amphibalanus amphitrite</i>
Online adgang:https://www.mdpi.com/1660-3397/20/2/124
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