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Human immunoglobulin from transchromosomic bovines hyperimmunized with SARS-CoV-2 spike antigen efficiently neutralizes viral variants

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants with amino-acid substitutions and deletions in spike protein (S) can reduce the effectiveness of monoclonal antibodies (mAbs) and may compromise immunity induced by vaccines. We report a polyclonal, fully human, anti-SARS-CoV-2 im...

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Principais autores: Zhuoming Liu, Hua Wu, Kristi A. Egland, Theron C. Gilliland, Matthew D. Dunn, Thomas C. Luke, Eddie J. Sullivan, William B. Klimstra, Christoph L. Bausch, Sean P. J. Whelan
Formato: Artigo
Idioma:Inglês
Publicado: Taylor & Francis Group 2022-04-01
Series:Human Vaccines & Immunotherapeutics
Assuntos:
sars-cov-2
variants
polyclonal antibodies
transchromosomic bovines
Acceso en liña:http://dx.doi.org/10.1080/21645515.2021.1940652
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