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Inhibiting thromboinflammation with a designed peptide that blocks the IL-1β-FXIa axis uncouples antithrombosis from bleeding risk

Abstract The complex interplay between inflammation and coagulation drives thromboinflammatory disorders. While previous studies have shown that interleukin-1β (IL-1β) can induce a hypercoagulable state in response to tissue hypoxia and inflammation, the specific mechanisms of its action on the coag...

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Kaydedildi:
Asıl Yazarlar: Yuewei Wang, Qikai Yin, Xin Jiang, Wenshuo Li, Musan Yan, Chuanfeng Liu, Shaoying Wang, Mengmeng Wang, Shiping Lin, Xin Jin, Min Xue, Xiaopeng Tang
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Springer 2026-04-01
Seri Bilgileri:Cellular and Molecular Life Sciences
Konular:
IL-1β
Thromboinflammation
Anticoagulants
Bleeding risk
Ischemic stroke
Online Erişim:https://doi.org/10.1007/s00018-026-06205-1
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