Development of a Human 3D Immune‐Competent Neurovascular Model Enabling Time‐Resolved Monitoring of Neuroinflammatory Dynamics and Neuroimmune Interactions

ABSTRACT Neuroinflammation disrupts the blood–brain barrier (BBB) and drives neurological disease, but current in vitro MPS and animal models fail to capture its dynamic, human‐specific immune complexity. Here, we introduce a 3D human immune‐competent BBB (3D‐HIC‐BBB) platform that reconstitutes the...

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Detalhes bibliográficos

Principais autores:	Pavlo Gordiichuk, Jing Bai, Olurotimi A. Bolonduro, Andrew M. Silverman, Robert Madison Green, Jason H. Lasser, Paul W. Fleming, Lishomwa C. Ndhlovu, James F. Saunders, Dmitry Shvartsman
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Wiley 2026-07-01
coleção:	Advanced Science
Assuntos:	blood–brain barrier microfluidics microphysiological systems neuroinflammation organoids TEER
Acesso em linha:	https://doi.org/10.1002/advs.75461
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