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Characterization of cxorf21 Provides Molecular Insight Into Female-Bias Immune Response in SLE Pathogenesis

Background: Ninety percent of systemic lupus erythematosus (SLE) patients are women. X chromosome-dosage increases susceptibility to SLE and primary Sjögren's syndrome (pSS). Chromosome X open reading frame 21 (CXorf21) escapes X-inactivation and is an SLE risk gene of previously unknown function. W...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Valerie M. Harris, Kristi A. Koelsch, Biji T. Kurien, Isaac T. W. Harley, Jonathan D. Wren, John B. Harley, R. Hal Scofield
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2019-10-01
Schriftenreihe:Frontiers in Immunology
Schlagworte:
sex-bias
systemic lupus erythematosus
innate immunity
X-chromosome
Interferon-inducible
Online-Zugang:https://www.frontiersin.org/article/10.3389/fimmu.2019.02160/full
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