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The adhesion GPCR ADGRV1 controls glutamate homeostasis in hippocampal astrocytes supporting neurons

Abstract ADGRV1 is the largest member of adhesion G protein-coupled receptor (aGPCR) family. In the cell, aGPCRs serve in two major functions, namely in cell adhesion and signal transduction. Mutations in ADGRV1 were linked not only to Usher syndrome (USH), which causes deaf-blindness, but recently,...

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Principais autores: Baran E. Güler, Mark Zorin, Joshua Linnert, Kerstin Nagel-Wolfrum, Uwe Wolfrum
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2026-04-01
Serier:Acta Neuropathologica Communications
Fag:
Adhesion GPCR
VLGR1
Epilepsy
Usher syndrome
Astroglia
Glutamate-glutamine cycle
Online adgang:https://doi.org/10.1186/s40478-026-02282-2
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