Alpha-synuclein shapes monocyte and macrophage cell biology and functions by bridging alterations of autophagy and inflammatory pathways

Introduction: Abnormal spreading of alpha-synuclein (αS), a hallmark of Parkinson’s disease, is known to promote peripheral inflammation, which occurs in part via functional alterations in monocytes/macrophages. However, underlying intracellular mechanisms remain unclear.Methods: Herein we investiga...

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Detalhes bibliográficos

Principais autores:	Fiona Limanaqi, Silvia Zecchini, Pasquale Ogno, Valentina Artusa, Claudio Fenizia, Irma Saulle, Claudia Vanetti, Micaela Garziano, Sergio Strizzi, Daria Trabattoni, Mario Clerici, Mara Biasin
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2024-07-01
coleção:	Frontiers in Cell and Developmental Biology
Assuntos:	cell survival cell toxicity p62 lysosomes cell migration chemotaxis
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fcell.2024.1421360/full
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