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Small-Molecule Chemical Knockdown of MuRF1 in Melanoma Bearing Mice Attenuates Tumor Cachexia Associated Myopathy

Patients with malignant tumors frequently suffer during disease progression from a syndrome referred to as cancer cachexia (CaCax): CaCax includes skeletal muscle atrophy and weakness, loss of bodyweight, and fat tissues. Currently, there are no FDA (Food and Drug Administration) approved treatments...

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Principais autores: Volker Adams, Victoria Gußen, Sergey Zozulya, André Cruz, Anselmo Moriscot, Axel Linke, Siegfried Labeit
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2020-10-01
Serier:Cells
Fag:
cancer cachexia
melanoma tumors
muscle wasting
mitochondrial metabolism
MuRF1
chemical biology
Online adgang:https://www.mdpi.com/2073-4409/9/10/2272
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