expHRD: an individualized, transcriptome-based prediction model for homologous recombination deficiency assessment in cancer

Abstract Background Homologous recombination deficiency (HRD) stands as a clinical indicator for discerning responsive outcomes to platinum-based chemotherapy and poly ADP-ribose polymerase (PARP) inhibitors. One of the conventional approaches to HRD prognostication has generally centered on identif...

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Autors principals:	Jae Jun Lee, Hyun Ju Kang, Donghyo Kim, Si On Lim, Stephanie S. Kim, Gahyun Kim, Sanguk Kim, Jin-Ku Lee, Jinho Kim
Format:	Artigo
Idioma:	Inglês
Publicat:	BMC 2024-07-01
Col·lecció:	BMC Bioinformatics
Matèries:	Homologous recombination deficiency scarHRD Transcriptome Elastic net regression Bootstrap
Accés en línia:	https://doi.org/10.1186/s12859-024-05854-y
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