Molecular details of the CPSF73-CPSF100 C-terminal heterodimer and interaction with Symplekin

Eukaryotic pre-mRNA is processed by a large multiprotein complex to accurately cleave the 3′ end, and to catalyse the addition of the poly(A) tail. Within this cleavage and polyadenylation specificity factor (CPSF) machinery, the CPSF73/CPSF3 endonuclease subunit directly contacts both CPSF100/CPSF2...

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Номзүйн дэлгэрэнгүй

Үндсэн зохиолчид:	Stéphane Thore, Finaritra Raoelijaona, Vincent Talenton, Sébastien Fribourg, Cameron D. Mackereth
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	The Royal Society 2023-11-01
Цуврал:	Open Biology
Нөхцлүүд:	protein structure pre-mRNA processing NMR spectroscopy cleavage and polyadenylation specificity factor
Онлайн хандалт:	https://royalsocietypublishing.org/doi/10.1098/rsob.230221
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!