Helicobacter pylori VacA modulates TRAF1-mediated 4-1BB/NF-kappaB axis to induce host apoptosis and chronic inflammatory damage

Abstract Background Helicobacter pylori (Hp) infection is the primary cause of gastric cancer. We previously demonstrated that TRAF1 expression was significantly increased during the multistep pathological timeline of Correa’s cascade and that these changes were closely correlated with Hp virulence...

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Detaylı Bibliyografya
Asıl Yazarlar: Lingzhi Yuan, Shuoyi Yao, Nanfang Qu, Xinmeng Li, Xueer Yang, Aojian Deng, Minglin Zhang, Ting Cai, Lunxi Liang, Zhitao Liu, Xiaoming Liu, Fen Wang
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: BMC 2025-10-01
Seri Bilgileri:Molecular Medicine
Konular:
Helicobacter pylori
VacA
TRAF1/4-1BB
NF-κB
IL-8
Cell proliferation and apoptosis
Online Erişim:https://doi.org/10.1186/s10020-025-01349-5
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