Patient induced pluripotent stem cells identify specificities of a reticular pseudodrusen phenotype in age-related macular degeneration

Abstract Background Age-related macular degeneration (AMD) is a leading cause of vision loss. Reticular pseudodrusen (RPD), deposits on the apical side of the retinal pigment epithelium (RPE), signify a distinctive and critical AMD phenotype. Yet, their molecular basis and relationship to the conven...

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Detalhes bibliográficos

Principais autores:	Jenna C. Hall, Kavitha Krishna Sudhakar, Maciej Daniszewski, Anne Senabouth, Carla J. Abbott, Helena H. Liang, Himeesh Kumar, Grace E. Lidgerwood, Mehdi Mirzaei, Jessica YW Ma, Trevor Atkeson, Yumiko Hirokawa, Emeline F. Nandrot, Alexander Barnett, Chantal Cazevieille, Gaël Manes, Simon Mountford, Philip Thompson, Erica L. Fletcher, Zhichao Wu, Melanie Bahlo, Brendan R. E. Ansell, Daniel Paull, Alex W. Hewitt, Robyn H. Guymer, Joseph E. Powell, Alice Pébay
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2026-05-01
coleção:	Genome Medicine
Assuntos:	Human induced pluripotent stem cells Retinal pigment epithelium Single-cell RNA sequencing Genome regulation Age-related macular degeneration Reticular pseudodrusen
Acesso em linha:	https://doi.org/10.1186/s13073-026-01658-2
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