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Adapalene inhibits the growth of triple-negative breast cancer cells by S-phase arrest and potentiates the antitumor efficacy of GDC-0941

Although advances in diagnostics and therapeutics have prolonged the survival of triple-negative breast cancer (TNBC) patients, metastasis, therapeutic resistance, and lack of targeted therapies remain the foremost hurdle in the effective management of TNBC. Thus, evaluation of new therapeutic agent...

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Principais autores: Umar Mehraj, Nissar Ahmad Wani, Abid Hamid, Mustfa Alkhanani, Abdullah Almilaibary, Manzoor Ahmad Mir
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2022-08-01
coleção:Frontiers in Pharmacology
Assuntos:
Breast cancer
triple-negative breast cancer
adapalene
combination therapy
Chou–Talalay
GDC-0941
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fphar.2022.958443/full
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