A Phase 1 trial of autologous monocytes stimulated ex vivo with Sylatron® (Peginterferon alfa-2b) and Actimmune® (Interferon gamma-1b) for intra-peritoneal administration in recurrent ovarian cancer

Abstract Background Ovarian cancer has no definitive second line therapeutic options, and largely recurs in the peritoneal cavity. Locoregional immune therapy using both interferons and monocytes can be used as a novel approach. Interferons have both cytostatic and cytotoxic properties, while monocy...

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Hauptverfasser:	Daniel S. Green, Ana T. Nunes, Virginia David-Ocampo, Irene B. Ekwede, Nicole D. Houston, Steven L. Highfill, Hanh Khuu, David F. Stroncek, Seth M. Steinberg, Kathryn C. Zoon, Christina M. Annunziata
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2018-07-01
Schriftenreihe:	Journal of Translational Medicine
Schlagworte:	Cellular therapy Immunotherapy Monocytes Interferons Ovarian cancer Intraperitoneal
Online-Zugang:	http://link.springer.com/article/10.1186/s12967-018-1569-5
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