CD126hi umbilical cord mesenchymal stem cells sensitive to IL-6 ameliorate inflammatory bowel disease by producing TGF-β1

Abstract Background Human umbilical cord mesenchymal stem cells (HUMSCs) are effective therapies for inflammatory bowel disease. However, the mechanisms remain unresolved. We found HUMSCs express CD126 (IL-6 receptor), which indicated CD126 sub-populations might show a distinct response to inflammat...

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Detalhes bibliográficos

Principais autores:	Yanxia Fu, Bingchen Xie, Yinyin Wang, Jianqiu Sheng, Zhijie Chang, Xiaojue Qiu, Dongliang Yu, Junfeng Xu
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2025-08-01
coleção:	Orphanet Journal of Rare Diseases
Assuntos:	Inflammatory bowel disease Human umbilical cord mesenchymal stem cells Inflammation T helper cells
Acesso em linha:	https://doi.org/10.1186/s13023-025-03993-w
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