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MiR-223 enhances lipophagy by suppressing CTSB in microglia following lysolecithin-induced demyelination in mice

Abstract Background Lipid droplet (LD)-laden microglia is a key pathological hallmark of multiple sclerosis. The recent discovery of this novel microglial subtype, lipid-droplet-accumulating microglia (LDAM), is notable for increased inflammatory factor secretion and diminished phagocytic capability...

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Main Authors: Hao Ma, Zhi-lin Ou, Nima Alaeiilkhchi, Yong-quan Cheng, Kai Chen, Jia-yu Chen, Ru-qin Guo, Min-yue He, Shi-yi Tang, Xin Zhang, Zhi-ping Huang, Junhao Liu, Jie Liu, Qing-an Zhu, Zu-cheng Huang, Hui Jiang
Format: Artigo
Language:Inglês
Published: BMC 2024-06-01
Series:Lipids in Health and Disease
Subjects:
Demyelination
MiR-223
Lipid droplets
Lipophagy
Microglia
CTSB (cathepsin B)
Online Access:https://doi.org/10.1186/s12944-024-02185-y
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