Loss of the Yeast SR Protein Npl3 Alters Gene Expression Due to Transcription Readthrough.

Yeast Npl3 is a highly abundant, nuclear-cytoplasmic shuttling, RNA-binding protein, related to metazoan SR proteins. Reported functions of Npl3 include transcription elongation, splicing and RNA 3' end processing. We used UV crosslinking and analysis of cDNA (CRAC) to map precise RNA binding sites,...

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Autors principals:	Rebecca K Holmes, Alex C Tuck, Chenchen Zhu, Hywel R Dunn-Davies, Grzegorz Kudla, Sandra Clauder-Munster, Sander Granneman, Lars M Steinmetz, Christine Guthrie, David Tollervey
Format:	Artigo
Idioma:	Inglês
Publicat:	Public Library of Science (PLoS) 2015-12-01
Col·lecció:	PLoS Genetics
Accés en línia:	https://doi.org/10.1371/journal.pgen.1005735
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