Chemotherapy induces feedback up-regulation of CD44v6 in colorectal cancer initiating cells through β-catenin/MDR1 signaling to sustain chemoresistance

Chemoresistance in colorectal cancer initiating cells (CICs) involves the sustained activation of multiple drug resistance (MDR) and WNT/β-catenin signaling pathways, as well as of alternatively spliced-isoforms of CD44 containing variable exon-6 (CD44v6). In spite of its importance, mechanisms unde...

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Autori principali:	Shibnath Ghatak, Vincent C. Hascall, Nikos Karamanos, Roger R. Markwald, Suniti Misra
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Frontiers Media S.A. 2022-10-01
Serie:	Frontiers in Oncology
Soggetti:	colon rectal cancer (CRC) cancer initiating cells (CICs) CD44v6 WNT3A MDR1
Accesso online:	https://www.frontiersin.org/articles/10.3389/fonc.2022.906260/full
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