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Immunoproteasome functions explained by divergence in cleavage specificity and regulation

The immunoproteasome (iP) has been proposed to perform specialized roles in MHC class I antigen presentation, cytokine modulation, and T cell differentiation and has emerged as a promising therapeutic target for autoimmune disorders and cancer. However, divergence in function between the iP and the...

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Detalhes bibliográficos
Principais autores: Michael B Winter, Florencia La Greca, Shirin Arastu-Kapur, Francesco Caiazza, Peter Cimermancic, Tonia J Buchholz, Janet L Anderl, Matthew Ravalin, Markus F Bohn, Andrej Sali, Anthony J O'Donoghue, Charles S Craik
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications Ltd 2017-11-01
coleção:eLife
Assuntos:
Acesso em linha:https://elifesciences.org/articles/27364
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