Endothelin receptor antagonists: effects on extracellular matrix synthesis in primary cultures of skin fibroblasts from systemic sclerosis patients

Endothelin-1 (ET-1) seems to enhance the pro-fibrotic protein synthesis by skin fibroblasts and its effects are mediated by endothelin-A and B (ETA and ETB) receptors. This study aimed to investigate the effects of ETA and ETB receptor antagonists (ETARA-sitaxentan and ETA/BRA-bosentan) on type I co...

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Autors principals:	B. Villaggio, B. Seriolo, A. Sulli, A. Parodio, C. Ferrone, R. Brizzolara, P. Montagna, S. Soldano, M. Cutolo
Format:	Artigo
Idioma:	Inglês
Publicat:	PAGEPress Publications 2012-12-01
Col·lecció:	Reumatismo
Matèries:	skin fibrosis, endothelin receptor antagonist, endothelin-1, extracellular matrix proteins, fibroblasts, systemic sclerosis
Accés en línia:	http://www.reumatismo.org/index.php/reuma/article/view/580
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