Enhanced durability of a Zika virus self-amplifying RNA vaccine through combinatorial OX40 and 4-1BB agonism

The SARS-CoV-2 pandemic highlighted the potential of mRNA vaccines in rapidly responding to emerging pathogens. However, immunity induced by conventional mRNA vaccines wanes quickly, requiring frequent boosters. Self-amplifying RNA (saRNA) vaccines, which extend antigen expression via self-replicati...

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Principais autores:	Hsueh-Han Lu, Rúbens Prince dos Santos Alves, Qin Hui Li, Luke Eder, Julia Timis, Henry Madany, Kantinan Chuensirikulchai, Krithik V. Varghese, Aditi Singh, Linda Le Tran, Audrey Street, Annie Elong Ngono, Michael Croft, Sujan Shresta
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Clinical investigation 2025-05-01
coleção:	JCI Insight
Assuntos:	Immunology Infectious disease Vaccines
Acesso em linha:	https://doi.org/10.1172/jci.insight.187405
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