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Institut Georges Lopez-2M as a Novel Lung Preservation Solution Attenuates Ischemia-Reperfusion Injury in a Rat Ex Vivo Lung Perfusion Model

InstitutGeorges Lopez-2M (IGL-2M), a novel preservation solution containing polyethylene glycol (PEG 35kD, 5 g/L), preserves mitochondrial integrity and redox balance in liver grafts. This study assesses IGL-2M’s effect on lung preservation during prolonged cold ischemia. Rat’s heart-lung blocks wer...

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Principais autores: Annalisa Barbarossa, Jan Van Slambrouck, Cara Trivett, Phéline Kortleven, Cedric Vanluyten, Alberto Martin Medina, Xin Jin, Nicole Jannis, Balin Özsoy, Sandra Claes, Dominique Schols, Tine Wylin, Karen Moermans, Steve Stegen, Arnau Panisello Rosello, Ilhan Inci, Paul De Leyn, Bart Vanaudenaerde, Jacques Pirenne, Elizabeth A. V. Jones, Laurens J. Ceulemans
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2026-02-01
coleção:Transplant International
Assuntos:
endothelial glycocalyx
ischemia-reperfusion injury
lung preservation
polyethylene glycol (PEG)
preservation solution
Acesso em linha:https://www.frontierspartnerships.org/articles/10.3389/ti.2026.15993/full
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