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Design and Synthesis of Chalcone Derivatives as Inhibitors of the Ferredoxin — Ferredoxin-NADP+ Reductase Interaction of Plasmodium falciparum: Pursuing New Antimalarial Agents

Some chalcones have been designed and synthesized using Claisen-Schmidt reactions as inhibitors of the ferredoxin and ferredoxin-NADP+ reductase interaction to pursue a new selective antimalaria agent. The synthesized compounds exhibited inhibition interactions between PfFd-PfFNR in the range of 10....

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Principais autores: Hery Suwito, Jumina, Mustofa, Pratiwi Pudjiastuti, Much Zaenal Fanani, Yoko Kimata-Ariga, Ritsuko Katahira, Toru Kawakami, Toshimichi Fujiwara, Toshiharu Hase, Hasnah Mohd Sirat, Ni Nyoman Tri Puspaningsih
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2014-12-01
coleção:Molecules
Assuntos:
methoxyamino chalcones
antimalarial
PfFd-PfFNR inhibitor
Acesso em linha:http://www.mdpi.com/1420-3049/19/12/21473
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