Improving regioselectivity of phenylalanine aminomutase from Taxus chinensis by semi-rational mutagenesis for the biocatalytic amination of cinnamates

The occupancy of the binding pocket by the substrate ultimately determines the outcome of enzyme catalysis. Previous engineering and substrate scope of phenylalanine aminomutase from Taxus chinensis (TcPAM) has generated valuable knowledge about the regioselectivity with biocatalytic potentials for...

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Principais autores:	Tao Tang, Miao Wang, Yunyun Zhang, Yijun Chen
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2024-08-01
coleção:	Frontiers in Bioengineering and Biotechnology
Assuntos:	biocatalysis enzyme engineering phenylalanine aminomutase regioselectivity phenylalanine derivatives
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fbioe.2024.1417962/full
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