Neoadjuvant ultrahypofractionated radiotherapy with simultaneous integrated boost for glioblastoma: study protocol for a phase I multicenter clinical trial

Abstract Background The Stupp protocol standardized adjuvant radiotherapy (RT) with temozolomide as the best treatment after glioblastoma (GBM) resection. Later phase III trials found that moderate hypofractionation and ultrahypofractionation were not inferior in elderly or frail patients. As most r...

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Glavni autori:	Nadia Di Muzio, Miriam Torrisi, Raffaella Barzaghi, Arianna Pocaterra, Martina Mori, Filippo Folchini, Laura Giannini, Micol Valle, Michele Bailo, Chiara Lucrezia Deantoni, Silvia Snider, Filippo Gagliardi, Eliana Ruggiero, Sara Broggi, Luca Ruffino, Rossella Di Franco, Simona Mercogliano, Claudio Fiorino, Antonella Del Vecchio, Matteo Muto, Paolo Muto, Pietro Mortini, Anna Mondino, Andrei Fodor
Format:	Artigo
Jezik:	Inglês
Izdano:	BMC 2026-04-01
Serija:	BMC Cancer
Teme:	Glioblastoma Neoadjuvant radiotherapy Stereotactic radiotherapy Simultaneous integrated boost Magnetic resonance imaging Clinical prospective trial
Online pristup:	https://doi.org/10.1186/s12885-026-15950-2
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