Chemo-enzymatic total syntheses of bis-tetrahydroisoquinoline alkaloids and systematic exploration of the substrate scope of SfmC

Chemo-enzymatic hybrid process merging enzymatic cascade reactions of designed substrates with chemo- and site-selective synthetic manipulations allowed the chemo-enzymatic total syntheses of jorunnamycin A and saframycin A, in just 4 and 5 pots processes, respectively. Artificial variants with inst...

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Bibliografische gegevens

Hoofdauteurs:	Ryo Tanifuji, Naoto Haraguchi, Hiroki Oguri
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	Elsevier 2022-03-01
Reeks:	Tetrahedron Chem
Onderwerpen:	Chemo-enzymatic synthesis Tetrahydroisoquinoline alkaloids Non-ribosomal peptide synthetase Total synthesis
Online toegang:	http://www.sciencedirect.com/science/article/pii/S2666951X22000067
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