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Immunological and homeostatic pathways of alpha -1 antitrypsin: a new therapeutic potential

α -1 antitrypsin (A1AT) is a 52 kDa acute-phase glycoprotein belonging to the serine protease inhibitor superfamily (SERPIN). It is primarily synthesized by hepatocytes and to a lesser extent by monocytes, macrophages, intestinal epithelial cells, and bronchial epithelial cells. A1AT is encoded by S...

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Principais autores: Carmen Mazzuca, Laura Vitiello, Silvia Travaglini, Fatima Maurizi, Panaiotis Finamore, Simona Santangelo, Amelia Rigon, Marta Vadacca, Silvia Angeletti, Simone Scarlata
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2024-08-01
coleção:Frontiers in Immunology
Assuntos:
serine protease inhibitor superfamily (SERPIN)
anti-inflammation
autoimmune disease
infectious disease
Severe Acute Respiratory Syndrome Coronavirus2 (SARS-CoV-2)
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1443297/full
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