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Artificial intelligence-derived neurofibrillary tangle burden is associated with antemortem cognitive impairment

Abstract Tauopathies are a category of neurodegenerative diseases characterized by the presence of abnormal tau protein-containing neurofibrillary tangles (NFTs). NFTs are universally observed in aging, occurring with or without the concomitant accumulation of amyloid-beta peptide (Aβ) in plaques th...

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Huvudupphov: Gabriel A. Marx, Daniel G. Koenigsberg, Andrew T. McKenzie, Justin Kauffman, Russell W. Hanson, Kristen Whitney, Maxim Signaevsky, Marcel Prastawa, Megan A. Iida, Charles L. White, Jamie M. Walker, Timothy E. Richardson, John Koll, Gerardo Fernandez, Jack Zeineh, Carlos Cordon-Cardo, John F. Crary, Kurt Farrell, The PART working group
Materialtyp: Artigo
Språk:Inglês
Utgiven: BMC 2022-10-01
Serie:Acta Neuropathologica Communications
Ämnen:
Tauopathy
Alzheimer’s disease
Primary age-related tauopathy
Neurofibrillary tangle
Digital pathology
Convolutional neural network
Länkar:https://doi.org/10.1186/s40478-022-01457-x
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