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Molecular insights into the effect of 1,6-hexanediol on FUS phase separation

Abstract The alkanediol 1,6-hexanediol has been widely used to dissolve liquid–liquid phase-separated condensates in cells and in vitro, but the details of how it perturbs the molecular interactions underlying liquid–liquid assembly remain unclear. In this study we use a combination of microscopy, n...

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Bibliografiske detaljer
Principais autores: Tongyin Zheng, Noah Wake, Shuo-Lin Weng, Theodora Myrto Perdikari, Anastasia C Murthy, Jeetain Mittal, Nicolas L Fawzi
Format: Artigo
Sprog:Inglês
Udgivet: Springer Nature 2025-04-01
Serier:The EMBO Journal
Fag:
Online adgang:https://doi.org/10.1038/s44318-025-00431-2
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