USP39 phase separates into the nucleolus and drives lung adenocarcinoma progression by promoting GLI1 expression

Abstract Background Intracellular membraneless organelles formed by liquid-liquid phase separation (LLPS) function in diverse physiological processes and have been linked to tumor-promoting properties. The nucleolus is one of the largest membraneless organelle formed through LLPS. Deubiquitylating e...

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Detalhes bibliográficos

Principais autores:	Shaoxuan Cheng, Zhiyuan Qiu, Ziyi Zhang, Yuxuan Li, Yue Zhu, Yuxin Zhou, Yinghui Yang, Yaowen Zhang, Dian Yang, Yingqiu Zhang, Han Liu, Zhaoxia Dai, Shu-Lan Sun, Shuyan Liu
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2025-01-01
coleção:	Cell Communication and Signaling
Assuntos:	LLPS Nucleolus USP39 GLI1 Lung adenocarcinoma
Acesso em linha:	https://doi.org/10.1186/s12964-025-02059-5
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