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Targeting ANT1 to regulate PINK1/Parkin-mediated mitophagy is an effective treatment of trauma-induced tendon heterotopic ossification

Background: Heterotopic ossification (HO) is a common degenerative disease following trauma. Tendon HO is primarily attributed to osteogenic differentiation of stem/progenitor cells within the tendon. However, the precise mechanism underlying this process remains unclear. Recent studies suggest that...

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Principais autores: Guanzhi Li, Tong Li, Ye Deng, Xiao Deng, Chao Chen, Bin Yu, Kairui Zhang
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2025-11-01
Serier:Journal of Orthopaedic Translation
Fag:
Trauma
Tendon
Heterotopic ossification
Mitophagy
ANT1
Elamipretide
Online adgang:http://www.sciencedirect.com/science/article/pii/S2214031X25001329
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