The coupling of global brain activity and cerebrospinal fluid flow as a potential predictive marker of brain amyloid-β accumulation

Background: Impaired cerebrospinal fluid (CSF) clearance is thought to contribute to amyloid-β (Aβ) accumulation in Alzheimer’s disease (AD). Global brain activity–CSF flow coupling (gBOLD–CSF coupling), measured through resting-state functional MRI, reflects CSF clearance capacity. A higher couplin...

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Hauptverfasser: Yuya Tanaka, Koji Kamagata, Yuya Saito, Kaito Takabayashi, Rinako Iseki, Wataru Uchida, Christina Andica, Akifumi Hagiwara, Akihiko Wada, Toshiaki Akashi, Osamu Abe, Shigeki Aoki
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2025-09-01
Schriftenreihe:The Journal of Prevention of Alzheimer's Disease
Schlagworte:
Alzheimer’s disease
Amyloid-β
Cerebrospinal fluid clearance
Glymphatic system
Resting-state functional MRI
gBOLD–CSF coupling
Online Zugang:http://www.sciencedirect.com/science/article/pii/S2274580725001712
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