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Muramyl dipeptide-mediated immunomodulation on monocyte subsets exerts therapeutic effects in a mouse model of Alzheimer’s disease

Abstract Background Muramyl dipeptide (MDP) is a component derived from minimal peptidoglycan motif from bacteria, and it is a ligand for the NOD2 receptor. Peripheral administration of MDP converts Ly6Chigh into Ly6Clow monocytes. Previously, we have shown that Ly6Clow monocytes play crucial roles...

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Detalhes bibliográficos
Principais autores: Adham Fani Maleki, Giulia Cisbani, Marie-Michèle Plante, Paul Préfontaine, Nataly Laflamme, Jean Gosselin, Serge Rivest
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2020-07-01
coleção:Journal of Neuroinflammation
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Acesso em linha:http://link.springer.com/article/10.1186/s12974-020-01893-3
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