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Large-scale next generation sequencing based analysis of SLCO1B1 pharmacogenetics variants in the Saudi population

Abstract Background SLCO1B1 plays an important role in mediating hepatic clearance of many different drugs including statins, angiotensin-converting enzyme inhibitors, chemotherapeutic agents and antibiotics. Several variants in SLCO1B1 have been shown to have a clinically significant impact, in rel...

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Principais autores: Ewa Goljan, Mohammed Abouelhoda, Asma Tahir, Mohamed ElKalioby, Brian Meyer, Dorota Monies
פורמט: Artigo
שפה:Inglês
יצא לאור: BMC 2024-03-01
סדרה:Human Genomics
נושאים:
Pharmacogenetics
SLCO1B1
Diplotypes
Phenotypes
Frequencies
Novel variants
גישה מקוונת:https://doi.org/10.1186/s40246-024-00594-9
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