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Identification of EGFR as an essential regulator in chondrocytes ferroptosis of osteoarthritis using bioinformatics, in vivo, and in vitro study

Objective: The mechanisms of chondrocytes ferroptosis in osteoarthritis (OA) have not yet been fully elucidated. This study aimed to identify key ferroptosis related genes (FRGs) involved in chondrocytes ferroptosis. Methods: LASSO, SVM-RFE, and receiver operating characteristic curve (ROC) were per...

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Principais autores: Hong Sun, Guoxuan Peng, Kunhao Chen, Zhilin Xiong, Yong Zhuang, Miao Liu, Xu Ning, Hua Yang, Jin Deng
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2023-09-01
Serier:Heliyon
Fag:
Osteoarthritis
Ferroptosis
Biomarkers
Ferroptosis related patterns
Competing endogenous RNA
EGFR
Online adgang:http://www.sciencedirect.com/science/article/pii/S2405844023071839
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