Eukaryotic Initiation Factor 5A2 localizes to actively translating ribosomes to promote cancer cell protrusions and invasive capacity

Abstract Background Eukaryotic Initiation Factor 5A (eIF-5A), an essential translation factor, is post-translationally activated by the polyamine spermidine. Two human genes encode eIF-5A, being eIF5-A1 constitutively expressed whereas eIF5-A2 is frequently found overexpressed in human tumours. The...

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Ngā kaituhi matua:	Arantxa Martínez-Férriz, Carolina Gandía, José Miguel Pardo-Sánchez, Alihamze Fathinajafabadi, Alejandro Ferrando, Rosa Farràs
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	BMC 2023-03-01
Rangatū:	Cell Communication and Signaling
Ngā marau:	Eukaryotic translation initiation factor 5A2 TGFB1 signaling Translating ribosomes Cytoskeleton organization Cell migration Lung adenocarcinoma
Urunga tuihono:	https://doi.org/10.1186/s12964-023-01076-6
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