Deep oncopanel sequencing reveals within block position-dependent quality degradation in FFPE processed samples

Abstract Background Clinical laboratories routinely use formalin-fixed paraffin-embedded (FFPE) tissue or cell block cytology samples in oncology panel sequencing to identify mutations that can predict patient response to targeted therapy. To understand the technical error due to FFPE processing, a...

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Detalhes bibliográficos

Principais autores:	Yifan Zhang, Thomas M. Blomquist, Rebecca Kusko, Daniel Stetson, Zhihong Zhang, Lihui Yin, Robert Sebra, Binsheng Gong, Jennifer S. Lococo, Vinay K. Mittal, Natalia Novoradovskaya, Ji-Youn Yeo, Nicole Dominiak, Jennifer Hipp, Amelia Raymond, Fujun Qiu, Hanane Arib, Melissa L. Smith, Jay E. Brock, Daniel H. Farkas, Daniel J. Craig, Erin L. Crawford, Dan Li, Tom Morrison, Nikola Tom, Wenzhong Xiao, Mary Yang, Christopher E. Mason, Todd A. Richmond, Wendell Jones, Donald J. Johann, Leming Shi, Weida Tong, James C. Willey, Joshua Xu
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2022-06-01
coleção:	Genome Biology
Assuntos:	Cancer genomics Next-generation sequencing FFPE Preanalytics Precision medicine Oncopanel sequencing
Acesso em linha:	https://doi.org/10.1186/s13059-022-02709-8
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