Efficacy of PRaG therapy in microsatellite-stable metastatic colorectal cancer: a comparative analysis of PD-1/PD-L1 inhibitor-based combination therapies

Abstract Background Most (95%) metastatic colorectal cancers (mCRCs) exhibit microsatellite stability (MSS) and proficiency in DNA mismatch repair (pMMR), leading to resistance to immunotherapy. To overcome this, the combination of programmed cell death protein 1 (PD-1)/programmed cell death ligand...

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Autors principals:	Jiabao Yang, Xiangrong Zhao, Pengfei Xing, Yuehong Kong, Meiling Xu, Liyuan Zhang
Format:	Artigo
Idioma:	Inglês
Publicat:	Springer 2025-10-01
Col·lecció:	Cancer Immunology, Immunotherapy
Matèries:	MSS/pMMR Colorectal cancer PD-1/PD-L1 inhibitor Radiotherapy Retrospective study
Accés en línia:	https://doi.org/10.1007/s00262-025-04185-y
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