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Self-organized anteroposterior regionalization of early midbrain and hindbrain/spinal cords using micropatterned human pluripotent stem cells

Anterior-posterior (AP) spatial regionalization is crucial for central nervous system development. Previous studies suggest that morphogen gradients can induce AP patterning in animal and organoid models. While self-organization in early embryogenesis and neurogenesis has been found using geometrica...

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Principais autores: Tianfa Xie, Han Jiang, Lauren E. Brown, ChangHui Pak, Yubing Sun
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2026-05-01
Serier:SLAS Technology
Fag:
Pluripotent stem cells
Anterior-posterior patterning
Midbrain
Micropatterning
Hindbrain
Spinal cords
Online adgang:http://www.sciencedirect.com/science/article/pii/S2472630326000324
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