Succinate in innate immunity: linking metabolic reprogramming to immune modulation

Succinate is an essential metabolite in the tricarboxylic acid (TCA) cycle. In mitochondria, succinate holds a unique position connecting the TCA cycle and the electron transport chain (ETC), thereby providing a shortcut path for adenosine triphosphate (ATP) production. Beyond this fundamental role...

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Bibliografiske detaljer

Principais autores:	Reham Atallah, Juergen Gindlhuber, Akos Heinemann
Format:	Artigo
Sprog:	Inglês
Udgivet:	Frontiers Media S.A. 2025-09-01
Serier:	Frontiers in Immunology
Fag:	succinate innate immune cells succinate dehydrogenase (SDH) reactive oxygen species (ROS) hypoxia-inducible factor-1α (HIF-1α) succinylation
Online adgang:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1661948/full
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