Inhibition of the Adenosine A_2A Receptor Mitigates Excitotoxic Injury in Organotypic Tissue Cultures of the Rat Cochlea

The primary loss of cochlear glutamatergic afferent nerve synapses due to noise or ageing (cochlear neuropathy) often presents as difficulties in speech discrimination in noisy conditions (hidden hearing loss (HHL)). Currently, there is no treatment for this condition. Our previous studies in mice w...

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Detalhes bibliográficos

Principais autores:	Belinda RX Han, Shelly CY Lin, Kristan Espinosa, Peter R Thorne, Srdjan M Vlajkovic
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2019-08-01
coleção:	Cells
Assuntos:	glutamate excitotoxicity cochlear synaptopathy cochlear explant adenosine A<sub>2A</sub> receptor istradefylline hidden hearing loss
Acesso em linha:	https://www.mdpi.com/2073-4409/8/8/877
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