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Discovery of curcumin inspired sulfonamide derivatives as a new class of carbonic anhydrase isoforms I, II, IX, and XII inhibitors

A series of curcumin inspired sulfonamide derivatives was prepared from various chalcones and 4-sulfamoyl benzaldehyde via Claisen–Schmidt condensation. All new compounds were assayed as inhibitors of four human isoforms of the metalloenzyme carbonic anhydrase (hCA, EC 4.2.1.1) isoforms hCA I, II, I...

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Principais autores: P. V. Sri Ramya, Srinivas Angapelly, Andrea Angeli, Chander Singh Digwal, Mohammed Arifuddin, Bathini Nagendra Babu, Claudiu T. Supuran, Ahmed Kamal
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis Group 2017-01-01
Serier:Journal of Enzyme Inhibition and Medicinal Chemistry
Fag:
Carbonic anhydrase
isoforms I, II, IX and XII
sulfonamide
curcumin
Online adgang:http://dx.doi.org/10.1080/14756366.2017.1380638
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