The roles of the mtDNA-cGAS-STING axis in tumor immunity: from immune activation to immune evasion

In the tumor microenvironment (TME), stress-induced mitochondrial DNA (mtDNA) leakage activates the mtDNA-cyclic GMP-AMP synthase (cGAS)- stimulator of interferon genes (STING) axis, which exerts a “double-edged sword” role in tumor immunity. On the one hand, it activates the STING- interferon regul...

Olles dieđut

Bibliográfalaš dieđut

Váldodahkkit:	Nan Huang, Zheng Liu, Haibo Lei, Xiang Liu
Materiálatiipa:	Artigo
Giella:	Inglês
Almmustuhtton:	Frontiers Media S.A. 2026-01-01
Ráidu:	Frontiers in Immunology
Fáttát:	immune activation immune evasion mtDNA-cGAS-STING tumor immune microenvironment tumor therapy
Liŋkkat:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1739559/full
Fáddágilkorat:	Lasit fáddágilkoriid Eai fáddágilkorat, Lasit vuosttaš fáddágilkora!