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Influence of the shared epitope on the effectiveness of biologic antirheumatic agents in European patients with rheumatoid arthritis

Background For rheumatoid arthritis (RA), the HLA-DRB1 ‘shared epitope’ (SE) allele has been proposed as a predictive biomarker for the effectiveness of mainly abatacept and other biologic disease-modifying antirheumatic drugs (bDMARDs).Objective To explore the relative impact of SE positivity on th...

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Principais autores: Bente Glintborg, Merete Lund Hetland, Ellen-Margrethe Hauge, Axel Finckh, Kim Lauper, Denis Mongin, Delphine S Courvoisier, Søren Jacobsen, Oliver Hendricks, Asta Linauskas, Dorte Vendelbo Jensen, Salome Kristensen, Oliver Distler, Lene Dreyer, Saedis Saevarsdottir, Diego Kyburz, Kari Stefansson, Torkell Ellingsen, Tue Wenzel Kragstrup, Estrid Høgdall, Burkhard Möller, Jens Kristian Pedersen, Heidi Lausten Munk, Ingileif Jonsdottir, Burkhard Moeller, Jean Villard, Romain Aymon, Johannes von Kempis, Anne Gitte Loft
Format: Artigo
Sprog:Inglês
Udgivet: BMJ Publishing Group 2026-07-01
Serier:RMD Open
Online adgang:https://rmdopen.bmj.com/content/12/3/e006788.full
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