FTD/ALS Type 7-Associated Thr104Asn Mutation of CHMP2B Blunts Neuronal Process Elongation, and Is Recovered by Knockdown of Arf4, the Golgi Stress Regulator

Frontotemporal dementia and/or amyotrophic lateral sclerosis type 7 (FTD/ALS7) is an autosomal dominant neurodegenerative disorder characterized by the onset of FTD and/or ALS, mainly in adulthood. Patients with some types of mutations, including the Thr104Asn (T104N) mutation of charged multivesicu...

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Auteurs principaux:	Remina Shirai, Mizuka Cho, Mikinori Isogai, Shoya Fukatsu, Miyu Okabe, Maho Okawa, Yuki Miyamoto, Tomohiro Torii, Junji Yamauchi
Format:	Artigo
Langue:	Inglês
Publié:	MDPI AG 2023-08-01
Collection:	Neurology International
Sujets:	CHMP2B N1E-115 cell neuronal differentiation Arf4 Golgi stress
Accès en ligne:	https://www.mdpi.com/2035-8377/15/3/63
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