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Chondrocyte expansion is associated with loss of primary cilia and disrupted hedgehog signalling

Tissue engineering-based therapies targeting cartilage diseases, such as osteoarthritis, require in vitro expansion of articular chondrocytes. A major obstacle for these therapies is the dedifferentiation and loss of phenotype accompanying chondrocyte expansion. Recent studies suggest that manipulat...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: CL Thompson, JCT Plant, AKT Wann, CL Bishop, P Novak, HM Mitchison, PL Beales, JP Chapple, MM Knight
Format: Artigo
Sprache:Inglês
Veröffentlicht: Forum Multimedia Publishing LLC 2017-09-01
Schriftenreihe:European Cells & Materials
Schlagworte:
Chondrocyte
dedifferentiation
re-differentiation
primary cilia
cilium
hedgehog
lithium chloride
Online-Zugang:http://www.ecmjournal.org/papers/vol034/pdf/v034a09.pdf
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